Lisinopril – An Overview of the Angiotensin-Converting Enzyme (ACE) Inhibitor Drug


Lisinopril (Hydrochlorothiazide)

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Overview of Lisinopril as an Angiotensin-Converting Enzyme (ACE) Inhibitor

Lisinopril is a popular drug classified as an angiotensin-converting enzyme (ACE) inhibitor. ACE inhibitors are widely prescribed medications used primarily in the treatment of hypertension (high blood pressure) and heart failure. They are also effective in managing certain cardiovascular conditions, such as reducing the risk of stroke in patients with left ventricular dysfunction.

How Does Lisinopril Work?

Lisinopril acts by inhibiting the action of ACE, an enzyme responsible for the production of a hormone called angiotensin II. Angiotensin II is a potent vasoconstrictor, which means it causes blood vessels to narrow, resulting in increased blood pressure. By blocking the production of this hormone, Lisinopril helps relax and widen the blood vessels, thereby lowering blood pressure and improving blood flow throughout the body.

Benefits of Lisinopril

Lisinopril offers several benefits:

  • Lowering Blood Pressure: Lisinopril effectively reduces high blood pressure, relieving strain on the heart and reducing the risk of cardiovascular complications.
  • Treatment of Heart Failure: Lisinopril is commonly used in the management of heart failure, helping the heart pump blood more efficiently and improving symptoms such as shortness of breath and fatigue.
  • Protection against Kidney Damage: People with diabetes or hypertension are often prone to kidney problems. Lisinopril has demonstrated its ability to protect the kidneys and slow down the progression of kidney disease.

Usage and Dosage

Lisinopril is typically taken orally, in the form of tablets or capsules, once or twice a day, as directed by a healthcare professional. The dosage may vary depending on the condition being treated and the individual patient’s response. It is important to follow the prescribed dosage and not to adjust it without medical advice.

Possible Side Effects

Lisinopril may cause certain side effects, although not everyone experiences them. Common side effects include:

  • Cough
  • Headache
  • Dizziness
  • Fatigue

These side effects are generally mild and transient. However, it is important to seek medical attention if any unusual or severe side effects occur.


As an ACE inhibitor, Lisinopril plays a crucial role in the management of hypertension, heart failure, and other cardiovascular conditions. Its ability to lower blood pressure, protect the kidneys, and improve heart function has made it a widely prescribed and effective medication. It is essential to follow the prescribed dosage and discuss any concerns or potential side effects with a healthcare professional.

For more information on Lisinopril, please visit the MedlinePlus website or consult with your healthcare provider.

2. Lisinopril: Benefits and Uses

Lisinopril is a widely prescribed medication belonging to the class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. This medication is commonly used to treat various cardiovascular conditions, including hypertension (high blood pressure) and heart failure.

High Blood Pressure:

One of the primary uses of Lisinopril is to manage high blood pressure. It works by relaxing the blood vessels, allowing the blood to flow more smoothly and reducing the pressure against the vessel walls. By controlling hypertension effectively, Lisinopril helps prevent complications such as heart attacks, strokes, and kidney problems.

According to the American Heart Association, hypertension is a major risk factor for cardiovascular diseases, and the use of medications like Lisinopril can significantly reduce this risk. It is important to note that Lisinopril may be prescribed alone or in combination with other blood pressure medications based on the individual’s condition.

Heart Failure:

Lisinopril is also commonly prescribed to individuals with heart failure. Heart failure occurs when the heart is unable to pump blood efficiently, leading to symptoms such as shortness of breath, fatigue, and fluid retention. The medication helps manage heart failure by reducing the workload on the heart and improving its ability to pump blood.

A study published in the New England Journal of Medicine found that ACE inhibitors, including Lisinopril, can significantly improve survival and reduce hospitalization rates in patients with heart failure. It is important to note that Lisinopril is just one component of a comprehensive treatment plan for heart failure, which may include lifestyle changes, other medications, and medical interventions.

Kidney Protection:

In addition to managing hypertension and heart failure, Lisinopril offers kidney protection benefits. It can slow the progression of kidney disease in individuals with diabetes and reduce the risk of kidney complications in people with high blood pressure. The medication achieves this by dilating blood vessels in the kidneys, improving blood flow, and reducing the pressure on these vital organs.

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The National Kidney Foundation recommends ACE inhibitors like Lisinopril as a first-line treatment for individuals with kidney disease, as they not only effectively control blood pressure but also provide additional renal benefits.

Other Uses:

While Lisinopril is primarily prescribed for hypertension, heart failure, and kidney protection, it may also be used in certain cases to manage other cardiovascular conditions, such as diabetic nephropathy and left ventricular dysfunction.


Lisinopril is a medication widely used for the management of hypertension, heart failure, and kidney protection. It helps control high blood pressure, improves heart function, and offers renal benefits. It is crucial to consult a healthcare professional for proper diagnosis, prescription, and guidance regarding the use of Lisinopril or any other medication.



Lisinopril (Hydrochlorothiazide)

Dosage: 10mg, 5mg

$1,33 per pill

Select Pack

3. Common uses of Lisinopril

Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is widely prescribed for its varied therapeutic benefits. This drug, available in tablet form, is primarily used for the following medical conditions:

  1. Hypertension: Lisinopril is extensively utilized in the treatment of high blood pressure. By inhibiting the ACE enzyme, it helps relax and widen the blood vessels, reducing the pressure exerted on the arterial walls. This enables better blood flow and helps normalize blood pressure levels, preventing cardiovascular complications.
  2. Heart failure: Lisinopril is also prescribed for patients suffering from heart failure. By suppressing the ACE enzyme, it helps decrease the strain on the heart and allows it to pump blood more efficiently. This can alleviate symptoms such as fatigue, shortness of breath, and fluid retention, improving the overall quality of life for individuals with heart failure.
  3. Post-heart attack therapy: After experiencing a heart attack, the heart’s ability to function properly may be compromised. Lisinopril is frequently administered as part of post-heart attack therapy to reduce the risk of subsequent heart failure and improve overall cardiac function. It plays a crucial role in preventing additional damage to the heart muscle and facilitating its recovery.
  4. Diabetic nephropathy: Diabetic nephropathy, a common complication of diabetes, involves damage to the kidneys due to prolonged high blood sugar levels. Lisinopril is often prescribed to individuals with diabetes to protect their kidneys and slow down the progression of kidney disease. By reducing the pressure within the kidney’s filtering units and limiting protein excretion, it helps preserve renal function.
  5. Migraine prevention: Although not primarily indicated for this purpose, some studies have suggested that Lisinopril may be effective in preventing migraines. However, more research is needed to establish its efficacy and safety in migraine prevention.

It’s important to note that Lisinopril should be used strictly as prescribed by a healthcare professional, and any deviations from the recommended dosage or usage should be discussed with a healthcare provider. The drug may also have potential side effects, including dizziness, cough, and allergic reactions, which should be promptly reported to a doctor.

For more detailed information on Lisinopril’s uses, dosage guidelines, and potential side effects, you can visit reputable sources such as the Mayo Clinic or National Center for Biotechnology Information (NCBI).

Point No. 4: Lisinopril Dosage and Administration

Lisinopril is available as oral tablets and should be taken according to the prescribed dosage and administration guidelines provided by your healthcare provider. It is important to follow these instructions carefully to ensure the safe and effective use of the medication.


The dosage of Lisinopril may vary depending on the individual patient, their medical condition, and other factors. The typical initial dosage for hypertension (high blood pressure) is 10 mg once daily. However, the dosage may be adjusted based on the patient’s response to the medication.

For patients with congestive heart failure, the initial dosage may be lower, starting at 2.5 mg once daily, and gradually increasing as tolerated. The maximum recommended dosage for heart failure is 40 mg per day.

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In some cases, Lisinopril may be prescribed concomitantly with diuretics, such as hydrochlorothiazide, to enhance its blood pressure-lowering effect. The dosage of both medications should be carefully monitored and adjusted as necessary.


Lisinopril tablets should be taken orally with a full glass of water. It is recommended to take the medication at the same time each day to maintain a consistent level of the drug in the bloodstream.

It is important not to chew, crush, or break the tablets before administration, as they are formulated to be swallowed whole. If you have difficulty swallowing the tablets, consult your healthcare provider for alternative dosage forms.

Special Populations

In certain populations, such as patients with renal impairment or those undergoing hemodialysis, the dosage of Lisinopril may need to be adjusted. Your healthcare provider will determine the appropriate dosage based on your individual needs and renal function.

For pediatric patients (6 years and older), the dosage of Lisinopril is based on weight. The maximum daily dosage for children is 0.6 mg/kg, not exceeding 40 mg per day. It is important to consult a pediatric specialist for the correct dosage calculation and guidance.

Important Considerations

It is crucial to adhere to the prescribed dosage and administration instructions to ensure the optimal therapeutic effect and minimize the risk of side effects. Do not modify the dosage or stop taking Lisinopril without consulting your healthcare provider.

If you miss a dose, take it as soon as you remember. However, if it is close to the time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for a missed one.

To learn more about Lisinopril dosage and administration, you can refer to the website. Always consult your healthcare provider or pharmacist for personalized guidance and further information.

5. Side effects of Lisinopril

Lisinopril, like any other medication, has the potential to cause side effects. It’s important to be aware of these potential side effects and to consult with a healthcare professional if you experience any of them. While not everyone may experience them, it’s important to be informed. Here are some of the possible side effects of Lisinopril:

  1. Dizziness: Some people may experience dizziness when taking Lisinopril. It is advisable to avoid driving or operating heavy machinery until you know how this medication affects you.
  2. Cough: Lisinopril may cause a persistent cough in some individuals. If the cough becomes bothersome or lasts for a prolonged period, it’s recommended to consult with your healthcare provider.
  3. Headache: Headaches are a common side effect of Lisinopril. If they are severe or persistent, it’s advisable to seek medical advice.
  4. Fatigue: Feeling tired or fatigued is another potential side effect of Lisinopril. If you experience excessive fatigue while taking this medication, it’s best to inform your healthcare provider.
  5. Nausea or vomiting: Some individuals may experience nausea or vomiting when taking Lisinopril. If the symptoms are severe or persistent, medical attention should be sought.
  6. Rash: Lisinopril can occasionally cause a skin rash. If you notice any abnormal skin changes or allergic reactions, it’s essential to notify your healthcare provider.

It is worth noting that this is not an exhaustive list of side effects, and other rare but serious side effects may occur. If you experience any unusual symptoms or side effects while taking Lisinopril, it’s crucial to contact a healthcare professional promptly.

Remember, this information is provided for educational purposes only, and it is important to consult with a healthcare provider or pharmacist for personalized advice and guidance on Lisinopril and its potential side effects.


Lisinopril (Hydrochlorothiazide)

Dosage: 10mg, 5mg

$1,33 per pill

Select Pack

6. How Lisinopril Works

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor, commonly prescribed for the treatment of high blood pressure (hypertension) and heart failure. This medication works by relaxing blood vessels, making it easier for the heart to pump blood through the body.

When you take Lisinopril, it inhibits the action of ACE, an enzyme responsible for the production of a hormone called angiotensin II. Angiotensin II is a potent vasoconstrictor, meaning it causes blood vessels to narrow. By blocking its production, Lisinopril helps to dilate blood vessels, reducing resistance to blood flow and lowering blood pressure.

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Additionally, Lisinopril helps to reduce the load on the heart by decreasing the amount of work it needs to do. This can be particularly beneficial for individuals with heart failure, as it allows the heart to pump more efficiently.

Lisinopril is also known to decrease the levels of aldosterone, a hormone that can contribute to fluid retention. By reducing aldosterone levels, Lisinopril helps to decrease fluid buildup and swelling in the body, known as edema.

Benefits of Lisinopril

The main benefits of using Lisinopril include:

  • Lowering blood pressure to reduce the risk of heart attack and stroke
  • Improving symptoms and outcomes in individuals with heart failure
  • Decreasing the progression of kidney disease in people with diabetes
  • Reducing the risk of future heart-related events in individuals with a history of heart attack or coronary artery disease

It’s important to note that Lisinopril should be taken regularly as prescribed by your healthcare provider and not stopped abruptly, as sudden withdrawal can lead to a rapid increase in blood pressure.

“According to the Mayo Clinic, Lisinopril is one of the most commonly prescribed medications for high blood pressure and heart failure.”

Remember to consult with your healthcare provider for personalized advice on whether Lisinopril is suitable for your medical condition, potential side effects, and any possible drug interactions.

Lisinopril Drug Interactions: How Lisinopril Interacts with Other Medications

When taking any medication, it is important to be aware of potential drug interactions that could affect its effectiveness or cause adverse reactions. Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, is no exception. Understanding how Lisinopril interacts with other medications can help you avoid potential risks and ensure the best possible outcomes.

1. Diuretics (Water Pills)

Lisinopril is often prescribed in combination with diuretics to treat high blood pressure and heart failure. However, the simultaneous use of diuretics with Lisinopril can increase the risk of low blood pressure (hypotension) and electrolyte imbalances.

2. Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

NSAIDs like ibuprofen, naproxen, and aspirin can reduce the effectiveness of Lisinopril in lowering blood pressure. They can also impair kidney function, which may further increase the risk of kidney problems when combined with Lisinopril.

3. Potassium Supplements and Potassium-Sparing Diuretics

Lisinopril can increase potassium levels in the body. Therefore, taking potassium supplements or using other potassium-sparing diuretics, such as spironolactone, could lead to dangerously high levels of potassium (hyperkalemia).

4. Lithium

When taken together, Lisinopril can decrease the excretion of lithium, leading to increased levels of lithium in the body. This can be toxic and require close monitoring of lithium levels if these medications are used concomitantly.

5. Diabetes Medications

Lisinopril may enhance the blood sugar-lowering effects of medications used to treat diabetes, such as insulin and oral hypoglycemic agents. As a result, patients with diabetes who are taking Lisinopril should carefully monitor their blood sugar levels to prevent hypoglycemia.

6. Other Antihypertensive Medications

Using other antihypertensive drugs alongside Lisinopril can significantly lower blood pressure. While combining antihypertensive medications may be necessary in some cases, close monitoring of blood pressure levels is crucial to ensure the blood pressure does not drop too low, leading to dizziness or fainting.

7. NSAID-Induced Kidney Injury Risk

It is important to note that Lisinopril, like other ACE inhibitors, can increase the risk of kidney injury when used in combination with NSAIDs. The risk is particularly high in elderly patients, those with pre-existing kidney conditions, or those using high doses of NSAIDs for prolonged periods. Close monitoring of renal function is necessary in these cases.

It is essential to inform your healthcare provider about all medications you are currently taking, including over-the-counter drugs, herbal supplements, and vitamins. They can evaluate potential interactions and make necessary adjustments to your treatment plan to ensure your safety and optimize therapeutic outcomes.

Category: Blood Pressure

Tags: Lisinopril, Hydrochlorothiazide